VICISSITUDE
vicissitude
(noun) mutability in life or nature (especially successive alternation from one condition to another)
vicissitude
(noun) a variation in circumstances or fortune at different times in your life or in the development of something; “the project was subject to the usual vicissitudes of exploratory research”
Source: WordNet® 3.1
Etymology
Noun
vicissitude (plural vicissitudes)
Regular change or succession from one thing to another, or one part of a cycle to the next; alternation; mutual succession; interchange.
Synonym: ups and downs (informal)
(often, in the plural) A change, especially in one's life or fortunes.
• Seneca
Source: Wiktionary
Vi*cis"si*tude, n. Etym: [L. vicissitudo, fr. vicis change, turn: cf.
F. vicissitude. See Vicarious.]
1. Regular change or succession from one thing to another;
alternation; mutual succession; interchange.
God made two great lights . . . To illuminate the earth and rule the
day In their vicissitude, and rule the night. Milton.
2. Irregular change; revolution; mutation.
This man had, after many vicissitudes of fortune, sunk at last into
abject and hopeless poverty. Macaulay.
Source: Webster’s Unabridged Dictionary 1913 Edition