LOCO

balmy, barmy, bats, batty, bonkers, buggy, cracked, crackers, daft, dotty, fruity, haywire, kooky, kookie, loco, loony, loopy, nuts, nutty, round the bend, around the bend, wacky, whacky

(adjective) informal or slang terms for mentally irregular; “it used to drive my husband balmy”

Source: WordNet® 3.1

Etymology 1

Adverb

loco (not comparable)

(music) A direction in written or printed music to be returning to the proper pitch after having played an octave higher or lower.

Etymology 2

Adjective

loco (comparative more loco, superlative most loco)

(colloquial) Crazy.

(Southwestern US) Intoxicated by eating locoweed.

Synonyms

• pea struck

Noun

loco (plural locos or locoes)

A certain species of Astragalus or Oxytropis, capable of causing locoism.

Synonym: locoweed

Verb

loco (third-person singular simple present locos, present participle locoing, simple past and past participle locoed)

(transitive) To poison with the loco plant; to affect with locoism.

(transitive, colloquial, by extension) To render insane.

• W. D. Howells

Etymology 3

Noun

loco (plural locos)

(rail transport, informal) A locomotive.

Anagrams

• COOL, Colo, Colo., Cool, colo, colo-, cool

Source: Wiktionary

Lo"co, adv. Etym: [It.] (Mus.)

Definition: A direction in written or printed music to return to the proper pitch after having played an octave higher.

Lo"co, n. Etym: [Sp. loco insane.] (Bot.)

Definition: A plant (Astragalus Hornii) growing in the Southwestern United States, which is said to poison horses and cattle, first making them insane. The name is also given vaguely to several other species of the same genus. Called also loco weed.

Source: Webster’s Unabridged Dictionary 1913 Edition