HEARTSICK
despondent, heartsick
(adjective) without or almost without hope; “despondent about his failure”; “too heartsick to fight back”
brokenhearted, heartbroken, heartsick
(adjective) full of sorrow
Source: WordNet® 3.1
Etymology
Adjective
heartsick (comparative more heartsick, superlative most heartsick)
Very despondent or sorrowful
Source: Wiktionary
Heart"sick`, a. Etym: [AS. heoriseĂłc.]
Definition: Sick at heart; extremely depressed in spirits; very despondent.
Source: Webster’s Unabridged Dictionary 1913 Edition