DOWNER
sedative, sedative drug, depressant, downer
(noun) a drug that reduces excitability and calms a person
Source: WordNet® 3.1
Etymology
Noun
downer (plural downers)
(slang) A negative drug trip.
(slang) A drug that has depressant qualities.
(slang) Something or someone disagreeable, dispiriting or depressing; a killjoy.
A livestock animal that has collapsed.
A form of industrial action in which workers down tools and refuse to work.
• C. T. B. Smith, ‎Great Britain. Dept. of Employment, Manpower Papers (issue 15, page 158)
Synonyms
• (something or someone disagreeable): buzzkill, killjoy, spoilsport; see also spoilsport
Anagrams
• Nedrow, Rowden, Wonder, Worden, wonder, wondre
Source: Wiktionary