SETBACK
reverse, reversal, setback, blow, black eye
(noun) an unfortunate happening that hinders or impedes; something that is thwarting or frustrating
Source: WordNet® 3.1
Etymology
Noun
setback (plural setbacks)
An obstacle, delay, disadvantage, blow (an adverse event which retards or prevents progress towards a desired outcome)
(US) The required distance between a structure and a road.
(architecture) A step-like recession in a wall.
An offset to the temperature setting of a thermostat to cover a period when more or less heating is required than usual.
(possibly archaic) A backset; a countercurrent; an eddy.
(archaic) A backset; a check; a repulse; a relapse.
Anagrams
• backest, backets, backset
Source: Wiktionary
Set"back`, n.
1. (Arch.)
Definition: Offset, n., 4.
2. A backset; a countercurrent; an eddy. [U. S.]
3. A backset; a check; a repulse; a reverse; a relapse. [Colloq.
U.S.]
Source: Webster’s Unabridged Dictionary 1913 Edition