MOXIE
backbone, grit, guts, moxie, sand, gumption
(noun) fortitude and determination; “he didn’t have the guts to try it”
Source: WordNet® 3.1
Etymology
Noun
moxie (uncountable) (US, informal)
Nerve, spunk, strength of character.
Synonyms: spirit, backbone, determination, fortitude
Verve.
Synonyms: vigor, pep, energy, initiative
Wit, smarts, skill.
Synonym: know-how
Usage notes
The origin of this word as the name of a popular product marketed as a cure-all may help to understand the logic behind the plurality of its similar meanings
The meanings can be grouped into "cures" for the problems of feeling too weak in spirit, body, or mind; in other words, of being overwhelmed/helpless, exhausted/listless, or confused/perplexed.
Anagrams
• oxime
Source: Wiktionary
Mox"ie, n. Etym: [fr. Moxie, a trade name for a beverage.]
1. energy; pep.
2. courage, determination.
3. Know-how, expertise. MW10.
Source: Webster’s Unabridged Dictionary 1913 Edition